Warning: Estradiol has been reported to increase the chance of womb (endometrial) cancer in women who have been through menopause. This risk appears to depend on the length of time this drug is used and the amount of estrogen per dose. If you use this drug for an extended period, you should be evaluated at least every 6 months. If you experience abnormal vaginal bleeding, notify your doctor promptly. This medication is not effective in preventing or treating a tendency toward miscarriages (natural habitual abortion) nor the threat of miscarriage. This drug must not be used during pregnancy because its use may result in birth defects or cancer later in the child's life. If you become pregnant or think you may be pregnant, consult your doctor immediately to discuss the risk to the fetus.

Before you take Estradiol, tell the prescribing doctor your entire medical history, including: family medical history (especially breast lumps and cancer), high blood pressure, diabetes, asthma, epilepsy (seizures), migraine headaches, liver disease, heart disease, kidney disease, depression, toxemia (high blood pressure during pregnancy), jaundice (yellowing skin/eyes) during pregnancy, excessive weight gain and fluid retention (bloating) during menstrual cycle, uterine fibroid tumor, abnormal vaginal bleeding, blood clots or stroke, cholesterol or lipid problems, gallbladder disease. Before having surgery, tell the doctor that you take this drug. Depending on strength, this drug may cause a patchy, darkening of the skin on the face (melasma). Higher strengths are more likely to cause melasma. Sunlight may intensify this darkening and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding use of sunscreens and protective clothing. Cigarette smoking can increase the chance of blood-clots while taking this medication (especially in women past the age of 35). This drug should not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. This drug may be excreted into breast milk and its use is not recommended while breast-feeding. Consult your doctor before breast-feeding.

Do not share Estradiol with others.

If you miss a dose of Estradiol, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Store Estradiol at room temperature between 59 and 86 degrees F (between 15 and 30 degrees C) away from moisture and sunlight. Do not store in the bathroom.

Estradiol is often misspelled, as many people hear the word verbally and write it down or spell it the incorrect way. Here are a few of the most common misspellings for Estradiol : Extradiol, Estrafiol, Extrafuel, Estrafuel, Extrasoil, Efradiol, Extraduel, Etradiol, Intradiol, Intrafoil. Full correct name of this drug is "Estradiol".